Attenuation of methamphetamine seeking by the mGluR2/3 agonist LY379268 in rats with histories of restricted and escalated self-administration

► We tested the effects of the specific mGluR2/3 agonist LY379268 on drug seeking. ► Stimulation of mGluR2/3 attenuated reinstatement of methamphetamine seeking. ► A regimen of greater drug exposure elevated sensitivity to mGluR2/3 treatment. ► The specificity of LY379268 effects was also shown using sucrose-trained rats.