Neuronal P2X3 receptor activation is essential to the hyperalgesia induced by prostaglandins and sympathomimetic amines released during inflammation

► Activation of neuronal P2X3 receptor is essential to the hyperalgesia. ► The P2X3 receptor activation leads to PKCɛ translocation. ► P2X3 primes the primary afferent neuron, increasing its response. ► Endogenous prostaglandin does not promote hyperalgesia by itself.