Immunotherapy blocking the tissue plasminogen activator-dependent activation of N-methyl-d-aspartate glutamate receptors improves hemorrhagic stroke outcome

► An antibody targeting NMDA receptors (αATD-GluN1) prevents the neurotoxicity of tPA. ► We evaluate the impact of αATD-GluN1 in a rat model of intracerebral hemorrhage (ICH). ► αATD-GluN1 decreases neuronal death as well as microglial activation after ICH. ► αATD-GluN1 decreases brain edema after ICH. ► αATD-GluN1 improves neurological outcome after ICH.