Novel multitarget ligand ITH33/IQM9.21 provides neuroprotection in in vitro and in vivo models related to brain ischemia

► ITH33/IQM9.21 is multitarget l-glutamic acid derivative designed for neuroprotection. ► It protects hippocampal slices subjected to oxygen and glucose deprivation. ► It reduces cerebral infarct volume even when administered 1 h post-stroke. ► It blocks intracellular calcium transients induced by glutamate and high K+. ► It stabilizes Ψm, and has anti-inflammatory and antioxidative actions.