Triterpene 3β, 6β, 16β trihidroxilup-20(29)-ene protects against excitability and oxidative damage induced by pentylenetetrazol: The role of Na+,K+-ATPase activity

► TTHL protects against pentylenetetrazol-induced electroencephalography seizures. ► Na+,K+-ATPase maintenance elicited by TTHL protects against toxicity induced by PTZ. ► TTHL has no antioxidant activity per se and not alter the [3H]flunitrazepam binding. ► TTHL attenuates EEG seizures induced by Na+,K+-ATPase inhibitor (ouabain). ► Anticonvulsant action elicited by TTHL involves Na+,K+-ATPase activity maintenance.