mTOR inhibition modulates epileptogenesis, seizures and depressive behavior in a genetic rat model of absence epilepsy

► Rapamycin blocks seizures and epileptogenesis in WAG/Rij rats. ► Acute and sub-chronic rapamycin has anti-absence properties. ► Rapamycin chronic (17 weeks) treatment has anti-epileptogenic effects. ► Rapamycin differentially modulates depressive behavior. ► Rapamycin blocks LPS-dependent seizure increase.