Energy depletion in seizures: Anaplerosis as a strategy for future therapies

► Seizures lead to energy failure and neuronal injury leading to deficits in patients. ► The TCA cycle is the primary source of energetic substrates. ► Mutation within the TCA cycle lead to epilepsy in humans. ► Anaplerosis is the replenishment of TCA cycle intermediates. ► Anaplerosis is a promising strategy to prevent seizures and associated cell death.