Seizure control by ketogenic diet-associated medium chain fatty acids

► Medium chain straight and branched fatty acids were examined for seizure control in vitro. ► Structural specificity was shown for these compounds. ► Side effects were examined for active seizure-control compounds. ► In vivo seizure control, sedation and neuroprotection were shown for these compounds. ► Medium chain fatty acids relating to the MCT ketogenic diet may be active in seizure control.