Ciliary neurotrophic factor activates NF-κB to enhance mitochondrial bioenergetics and prevent neuropathy in sensory neurons of streptozotocin-induced diabetic rodents

► Test hypothesis that CNTF modulates mitochondrial function. ► Study of sensory neurons in diabetic neuropathy. ► CNTF increased regeneration via NF-κB activity. ► CNTF treatment of diabetic mice prevented neuropathy and normalized deficient NF-κB. ► CNTF treatment of diabetic neurons optimized mitochondrial function via NF-κB.