Leukotriene D4 induces cognitive impairment through enhancement of CysLT1R-mediated amyloid-β generation in mice

► LTD4 may induce cognitive impairment in mice. ► LTD4-induced cognitive impairment is mediated by activation of CysLT1R. ► CysLT1R-trigered NF-κB signaling promotes Aβ generation through β-secretase pathway.