The role of transient receptor potential A 1 (TRPA1) in the development and maintenance of carrageenan-induced hyperalgesia

► TRPA1 blockade prevented and reversed carrageenan-induced inflammatory hyperalgesia. ► TRPA1 blockade did not affect neutrophil migration and cytokines expression. ► Neuronal TRPA1 gene silencing prevents carrageenan-induced inflammatory hyperalgesia.