Lithium attenuates methamphetamine-induced hyperlocomotion and behavioral sensitization via modulation of prefrontal monoamine release

► Li+ attenuates psychostimulant-induced hyperactivity and behavioral sensitization. ► Li+ attenuated acute METH-induced increase in prefrontal DA release. ► Li+ attenuated chronic METH-induced increase in prefrontal 5-HT release. ► 5-HT1A autoreceptor function may be involved in the effects of chronic METH and Li+.