Presynaptic muscarinic M2 receptors modulate glutamatergic transmission in the bed nucleus of the stria terminalis

► Endogenous ACh suppresses glutamate release in the BNSTALG. ► Effects are mimicked by muscarinic receptor agonists. ► Effects are mediated by presynaptic M2 receptors. ► EM studies confirm presynaptic M2 receptor expression in the BNSTALG.