Anticonvulsant profile of caprylic acid, a main constituent of the medium-chain triglyceride (MCT) ketogenic diet, in mice

► Ketogenic diet (KD) is highly effective in drug-resistant epilepsy. ► Its mechanism of action is unknown. ► Caprylic acid (CA) is the main constituent of the medium-chain triglyceride (MCT) KD. ► Here, CA showed acute anticonvulsant properties alone and in combination with valproate in mice. ► We propose, anticonvulsant properties of CA may add to the overall clinical efficacy of the MCT KD.