Atomoxetine modulates spontaneous and sensory-evoked discharge of locus coeruleus noradrenergic neurons

► Atomoxetine attenuates spontaneous firing rate of locus coeruleus neurons in vivo. ► Atomoxetine increases the phasic:tonic ratio of locus coeruleus response to stimuli. ► Atomoxetine modulates the average evoked field response in locus coeruleus. ► Atomoxetine modulates spike-field and cortical EEG-field coherence in locus coeruleus.