Antagonism of L-type Cav channels with nifedipine differentially affects performance of wildtype and NK1R−/− mice in the 5-Choice Serial Reaction-Time Task

► We compared the behavior of nifedipine-treated wildtype and NK1R−/− mice in the 5-CSRTT. ► Impulsivity and perseveration were reduced and inattentiveness was increased in both genotypes. ► Nifedipine was more potent in wildtypes than NK1R−/− mice. ► Accuracy was unaffected in either genotype. ► Functional coupling between NK1R and L-type channels affects cognitive performance.