The GABA system in anxiety and depression and its therapeutic potential

► A GABA deficit is a hallmark of anxiety disorders and major depression. ► Modulators of α2, α3 GABAA receptors are effective, non-sedative anxiolytics. ► Modulators of α2, α3 GABAA receptors are proposed as novel antidepressants. ► Eszopiclone co-therapy supports the novel concept of GABAergic antidepressants.