Pharmacological reversal of cognitive bias in the chick anxiety-depression model

► Cognitive biases can be reversed in individuals suffering from anxiety or depression. ► In depression-like states, imipramine reversed less optimistic-like behavior under ambiguous appetitive cues. ► In depression-like states, imipramine reversed more pessimistic-like behavior under ambiguous aversive cues. ► In anxiety-like states, clonidine was unable to reverse more pessimistic-like behavior under ambiguous aversive cues. ► In the anxiety-like states, clonidine produced modest sedation on runway performance.