On the mechanism of anti-hyperthermic effects of LY379268 and LY487379, group II mGlu receptors activators, in the stress-induced hyperthermia in singly housed mice

► The anti-hyperthermic efficacy of LY379268 is not dependent on GABA or serotonin. ► Blockade of GABAA receptor enhances anti-hyperhermic effect of LY487379 and LY379268. ► Blockade of 5HT receptors enhances anti-hyperhermic effect of LY487379 and LY379268.