The antidepressant-like effects of glutamatergic drugs ketamine and AMPA receptor potentiator LY 451646 are preserved in bdnf+/− heterozygous null mice

► The antidepressant-like effects of ketamine and LY 451646 are retained in bdnf+/− mice. ► The antidepressant-like effects of ketamine are not sustained for 7 days. ► Ketamine does not increases hippocampal BDNF levels or TrkB phosphorylation.