Age-dependent therapeutic effect of memantine in a mouse model of juvenile Batten disease

► We studied the therapeutic effect of memantine in a mouse model of Batten disease. ► Acute treatment had no effect on the impaired motor skills of 1-month-old mice. ► Acute treatment induced a prolonged improvement in 6-7-month-old Cln3Δex1-6 mice. ► Acute treatment in 6-7-month-old Cln3Δex1-6 mice did not affect neuropathology. ► Repeated treatment in 6-month-old Cln3Δex1-6 mice did not improve the motor skills.