Presynaptic α2-adrenoceptors control the inhibitory action of presynaptic CB1 cannabinoid receptors on prefrontocortical norepinephrine release in the rat

► CB1 receptors inhibit norepinephrine release from rat prefrontal cortex. ► Dual interaction between CB1 receptors and autoinhibition by α2-adrenoceptors. ► CB1 receptors and α2A receptors co-localize on noradrenergic varicosities.