Pharmacological modulation of amphetamine-induced dyskinesia in transplanted hemi-parkinsonian rats

► Peak amphetamine rotation requires a higher dose than that of peak dyskinesia. ► A variety of drugs can reduce l-DOPA induced dyskinesia in lesioned rats. ► Amphetamine induced dyskinesia is reduced by dopamine agonist and 5-HT drugs. ► Amphetamine induced dyskinesia is enhanced by MK-801. ► Dopamine receptor levels are not related to amphetamine-induced dyskinesia.