Lisdexamfetamine and immediate release d-amfetamine - Differences in pharmacokinetic/pharmacodynamic relationships revealed by striatal microdialysis in freely-moving rats with simultaneous determination of plasma drug concentrations and locomotor activit

► Pharmacokinetics and pharmacodynamics of lisdexamfetamine (LDX) and d-amfetamine. ► Microdialysis with simultaneous determination of locomotor activity and drug levels. ► LDX produced large increases in striatal dopamine efflux without locomotor activity. ► LDX is predicted to have a better therapeutic window than d-amfetamine.