Regulation of the ERK pathway in the dentate gyrus by in vivo dopamine D1 receptor stimulation requires glutamatergic transmission

► SKF81297 induced ERK, histone H3 and ribosomal S6 phosphorylation in the dentate gyrus requires group I mGluRs stimulation. ► PKC is involved in SKF81297 induced ERK cascade activation. ► Ribosomal S6 phosphorylation is independent of mTORC1 pathway.