Stimulation of adenosine receptors in the nucleus accumbens reverses the expression of cocaine sensitization and cross-sensitization to dopamine D2 receptors in rats

► Elevating adenosine levels in the accumbens reverses cocaine sensitization. ► A1 and A2A receptor stimulation in the accumbens reverses cocaine sensitization. ► Accumbens adenosine receptor stimulation does not affect acute cocaine sensitivity. ► A1-induced reversal of sensitization involves both A1 and A2A receptors. ► Accumbens A2A receptor stimulation reverses D2 receptor cross-sensitivity.