Erythropoietin promotes axonal regeneration after optic nerve crush in vivo by inhibition of RhoA/ROCK signaling pathway

► EPO promotes RGCs survival and axonal regeneration after optic nerve crush in vivo. ► EPO results in RhoA inactivation and increases expression of GAP-43 protein. ► RhoA/ROCK pathway is involved in the EPO effect to promote RGCs axon regeneration.