Acetylcholinesterase inhibitors rapidly activate Trk neurotrophin receptors in the mouse hippocampus

► Galantamine and donepezil activated TrkA and TrkB receptors in the mouse hippocampus. ► Galantamine and donepezil increased the phosphorylation of AKT and CREB in the mouse hippocampus. ► Chronic galantamine did not regulate BDNF or NGF synthesis in the mouse hippocampus.