Re-exposure and environmental enrichment reveal NPY-Y1 as a possible target for post-traumatic stress disorder

► Environmental enrichment (EE) and re-exposure (RE) enhanced behavioral recovery after foot shocks. ► RE normalized the foot shock (FS)-induced changes in glutamate receptor mRNAs in the amygdala. ► EE and RE normalized the FS-induced increase in CRF-R1 mRNA in the amygdala. ► RE and EE increased NPY-Y1 receptor mRNA in amygdala. ► Infusion of a NPY-Y1 agonist in the amygdala reduced FS-induced anxiety.