Differences in peripheral endocannabinoid modulation of scratching behavior in facial vs. spinally-innervated skin

► Pruritogen-evoked scratching behavior is greater in the rostral back vs. cheek. ► Intradermal URB597 and JZL184 reduced scratching in rostral back via CB1 and CB2. ► Intradermal URB597 and JZL184 increased itch- and pain-like behaviors in the cheek. ► Endocannabinoids differentially modulate scratching dependent on skin location.