Modeling treatment-resistant depression

► We compare and contrast the currently used animal models of depression. ► We examine how chronic corticosterone can model SSRI-resistant depression. ► We compare behavior tests used to determine antidepressant non-responder populations. ► We discuss the role of Serotonin 1A (5-HT1A) autoreceptors in resilience to stress. ► We discuss the role of Serotonin 1A (5-HT1A) autoreceptors in response to SSRIs.