The 5-HT6 serotonin receptor antagonist SB-271046 attenuates the development and expression of nicotine-induced locomotor sensitisation in Wistar rats

► Nicotine demonstrated pronounced behavioural sensitisation to its stimulant actions. ► The 5-HT6 receptor antagonist SB-271046 reduced the development and expression of nicotine sensitisation. ► These data suggest the utility of 5-HT6 receptor antagonists for reducing the effects of nicotine. ► Together, these data suggest that more detailed studies with 5-HT6 antagonists to reduce addiction are warrented.