Increased binding of cortical and hippocampal group II metabotropic glutamate receptors in isolation-reared mice

► The [3H]LY341495 binding was significantly increased by rearing in social isolation. ► The effect was specific for the prefrontal cortex and hippocampus. ► The Bmax value increased significantly without any changes in the Kd value. ► The mGluR2/3 antagonist showed an antidepressant effect in isolation-reared mice. ► The increased receptor function may contribute to the pathogenic mechanisms.