An intrinsic GABAergic system in human lymphocytes

►Human Lymphocytes have a functional GABAergic system, similar to the neuronal one. ► Lymphocytes express the necessary components to synthesize, store and degradate GABA. ► Lymphocytes also express functional GABA transporters and ionotropic receptor subunits. ► GABA and Muscimol inhibit lymphocyte proliferation.