کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5816656 | 1116149 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Riparoside B and timosaponin J, two steroidal glycosides from Smilax riparia, resist to hyperuricemia based on URAT1 in hyperuricemic mice
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کلمات کلیدی
Smilax ripariaFEUAEtOHURAT1HR-ESI-MSn-Butyl alcoholmGAPDHmOAT1XODmURAT1BuOHnuclear magnetic resonance - رزونانس مغناطیسی هستهایXanthine oxidase - زانتین اکسیدازUric acid - اسید اوریکethyl alcohol - الکل اتیلیکNMR - تشدید مغناطیسی هستهای BUN - خوبblood urea nitrogen - نیتروژن اوره خونHyperuricemia - هیپریریسمیcreatinine - کراتینینNormal control - کنترل عادیglyceraldehyde-3-phosphate dehydrogenase - گلیسرالیدید-3-فسفات دهیدروژنازSteroidal glycosides - گلیکوزید های استروئیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Riparoside B and timosaponin J, two steroidal glycosides from Smilax riparia, resist to hyperuricemia based on URAT1 in hyperuricemic mice Riparoside B and timosaponin J, two steroidal glycosides from Smilax riparia, resist to hyperuricemia based on URAT1 in hyperuricemic mice](/preview/png/5816656.png)
چکیده انگلیسی
The roots and rhizomes of Smilax riparia (SR), called “Niu-Wei-Cai” in traditional Chinese medicine (TCM), are believed to be effective in treating gout symptoms. However, it is not clear if the active constituents and uricosuric mechanisms of S. riparia support its therapeutic activities. In this study, we isolated two steroidal glycosides named riparoside B and timosaponin J from the total saponins of S. riparia. We then examined if these two compounds were effective in reducing serum uric acid levels in a hyperuricemic mouse model induced by potassium oxonate. We found that the two steroidal glycosides possess potent uricosuric effect in hyperuricemic mice through decreasing renal mURAT1 mainly and inhibiting XOD activity in a certain extent, which contribute to the enhancement of uric acid excretion and attenuate hyperuricemia-induced renal dysfunction. Riparoside B and timosaponin J may have a clinical utility in treating gout and other medical conditions caused by hyperuricemia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Phytomedicine - Volume 21, Issue 10, 15 September 2014, Pages 1196-1201
Journal: Phytomedicine - Volume 21, Issue 10, 15 September 2014, Pages 1196-1201
نویسندگان
Xiao-Hui Wu, Jun Zhang, Shu-Qing Wang, Victor C. Yang, Samantha Anderson, Yan-Wen Zhang,