کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5817006 1556704 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pre-treatment with α-hederin increases β-adrenoceptor mediated relaxation of airway smooth muscle
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
Pre-treatment with α-hederin increases β-adrenoceptor mediated relaxation of airway smooth muscle
چکیده انگلیسی
Preparations of ivy leaves dry extract with secretolytic and bronchiolytic efficacy are widely used for the treatment of acute and chronic obstructive airway diseases. The mechanism by which ivy preparations improve lung functions is not fully understood. Here, we tested the influence of the three main saponins of ivy, α-hederin, hederacoside C and hederagenin, on the contraction and relaxation behaviour of isolated bovine tracheal smooth muscle strips by isometric tension measurements. None of the tested compounds altered histamine or methacholine-induced contraction of the smooth muscle strips. In contrast, the isoprenaline-induced relaxation of 100 μM methacholine precontracted muscle strips was significantly enhanced when pre-treated with 1 μM of α-hederin for 18 h. The pre-treatment with hederacoside C or hederagenin had no effect on isoprenaline-induced relaxation. For the first time the bronchiolytic effect of α-hederin was demonstrated by isometric tension measurements using bovine tracheal smooth muscle strips. α-Hederin increases isoprenaline-induced relaxation indirectly, probably by inhibiting heterologous desensitization induced by high concentrations of muscarinic ligands like methacholine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Phytomedicine - Volume 18, Issues 2–3, 15 January 2011, Pages 214-218
نویسندگان
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