کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5817066 | 1116466 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Characterization of mammary adenocarcinomas in male rats after N-methyl-N-nitrosourea exposure-Potential for human male breast cancer model
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کلمات کلیدی
PCNAHER2NIEHSNTPPGRMNUN-methyl-N-nitrosoureaNIHGATA3H&E - H & EMammary adenocarcinoma - آدنوکارسینوم پستانProliferating Cell Nuclear Antigen - آنتیژن هسته ای تکثیر سلولیImmunohistochemistry - ایمونوهیستوشیمیNational Toxicology Program - برنامه سم شناسی ملیBreast cancer - سرطان پستانNational Institutes of Health - مؤسسات ملی بهداشتNational Institute of Environmental Health Sciences - موسسه ملی علوم بهداشت محیطMale rat - موش نرHematoxylin and Eosin - هماتوکسیلین و ائوزینGATA binding protein 3 - پروتئین گیرنده GATA 3Androgen Receptor - گیرنده آندروژنیEstrogen receptor α - گیرنده استروژن αProgesterone receptor - گیرنده پروژسترون
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
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چکیده انگلیسی
The frequency of breast cancer in men is extremely rare, reported to be less than 1% and there is currently no available animal model for male mammary tumors. We compared the characteristics of various immunohistochemical markers in N-methyl-N-nitrosourea (MNU)-induced mammary adenocarcinomas in male and female Crj:CD(SD)IGS rats including: estrogen receptor α (ER), progesterone receptor (PgR), androgen receptor (AR), receptor tyrosine-protein kinase erbB-2 (HER2), GATA binding protein 3 (GATA3), and proliferating cell nuclear antigen (PCNA). Female mammary adenocarcinomas were strongly positive in the nuclei of tumor cells for PCNA and ER (100%) with only 60% and 53% expressing PgR and GATA3, respectively. 100% of male adenocarcinomas also exhibited strongly positive expression in the nuclei of tumor cells for PCNA, with 25% expressing AR and only 8% showing positivity for ER. Male carcinomas did not express PgR or GATA3 and none of the tumors, male or female, were positive for HER2. Based on the observed ER and PgR positivity and HER2 negativity within these tumors, MNU-induced mammary adenocarcinomas in female rats appear to be hormonally dependent, similar to human luminal A type breast cancer. In contrast, MNU-induced mammary adenocarcinomas in male rats showed no reactivity for ER, PgR, HER2 or GATA3, suggesting no hormonal dependency. Both male and female adenocarcinomas showed high proliferating activity by PCNA immunohistochemistry. Based on our literature review, human male breast cancers are mainly dependent on ER and/or PgR, therefore the biological pathogenesis of MNU-induced male mammary cancer in rats may differ from that of male breast cancer in humans.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental and Toxicologic Pathology - Volume 68, Issue 5, May 2016, Pages 263-270
Journal: Experimental and Toxicologic Pathology - Volume 68, Issue 5, May 2016, Pages 263-270
نویسندگان
Katsuhiko Yoshizawa, Michiko Yuki, Yuichi Kinoshita, Yuko Emoto, Takashi Yuri, Nobuaki Shikata, Susan A. Elmore, Airo Tsubura,