کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5817182 | 1556838 | 2013 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Gene expression changes in rat brain after short and long exposures to particulate matter in Los Angeles basin air: Comparison with human brain tumors
ترجمه فارسی عنوان
بیان ژن در موش های موش پس از مواجهه کوتاه مدت و طولانی مدت با ذرات در هوا در حوضه لس آنجلس: مقایسه با تومورهای مغز انسان
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
چکیده انگلیسی
Arc/Arg3.1 and Rac1 genes, and their protein products were selected for further examination. Arc was elevated upon two-week to three-month exposure to coarse PM and declined after 10-month exposure. Rac1 was significantly elevated upon 10-month coarse PM exposure. On human brain tumor sections, Arc was expressed in benign meningiomas and low-grade gliomas but was much lower in high-grade tumors. Conversely, Rac1 was elevated in high-grade vs. low-grade gliomas. Arc is thus associated with early brain changes and low-grade tumors, whereas Rac1 is associated with long-term PM exposure and highly aggressive tumors. In summary, exposure to air PM leads to distinct changes in rodent brain gene expression similar to those observed in human brain tumors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental and Toxicologic Pathology - Volume 65, Issues 7â8, November 2013, Pages 1063-1071
Journal: Experimental and Toxicologic Pathology - Volume 65, Issues 7â8, November 2013, Pages 1063-1071
نویسندگان
Julia Y. Ljubimova, Michael T. Kleinman, Natalya M. Karabalin, Satoshi Inoue, Bindu Konda, Pallavi Gangalum, Janet L. Markman, Alexander V. Ljubimov, Keith L. Black,