Safety of Concomitant Metformin and Proton Pump Inhibitor Use: A Population Retrospective Cohort Study

Concomitant use of metformin and a PPI or metformin and an H2RA were associated with an increased risk of death or hospitalization. This finding suggests that the harm observed may not be due to a specific drug interaction but uncontrolled confounding secondary to an increased risk in those patients using a PPI or H2RA.