کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5827041 1558920 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Modulatory effect of diphenyl diselenide in Carioca High- and Low-conditioned Freezing rats
ترجمه فارسی عنوان
اثر تعدیل کننده دیفنیل دیئلناید در موش های سرد و سرخ شده کارایاکا
کلمات کلیدی
تهدید متضاد، اضطراب، دیفنیل دیئلناید، انجماد خط نان،
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
چکیده انگلیسی
Diphenyl diselenide ([PhSe]2)is an organoselenium compound that has interesting pharmacological properties, including antioxidant, glutathione peroxidase-mimetic, and neuroprotective effects. The objective of the present study was to investigate the possible modulatory effect of (PhSe)2 in 17th-generation Carioca high-and low-conditioned freezing (CHF and CLF) rats, an animal model of generalized anxiety disorders. (PhSe)2 was administered at three doses (10, 50, and 100 mg/kg) in CHF and CLF rats, and their anxiety-like profiles (conditioned freezing patterns) were measured before and 30 min after treatment. A significant difference was found in freezing scores between CHF and CLF animals before treatment (t70=12.50, p<0.001). Treatment with (PhSe)2 at 10 and 50 mg/kg decreased freezing in CHF rats but significantly increased freezing at 100 mg/kg. (PhSe)2 increased freezing in CLF animals at 50 and 100 mg/kg (p<0.01). These results indicate that (PhSe)2 exerts both anxiolytic- and anxiogenic-like effects in bi-directional rat lines. Distinct genetic profiles of the CHF and CLF lines may influence biochemical functions and lead to differential responses to aversive situations and various drugs like (PhSe)2.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 761, 15 August 2015, Pages 341-344
نویسندگان
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