کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5827528 | 1558931 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Protective effects of friedelin isolated from Azima tetracantha Lam. against ethanol-induced gastric ulcer in rats and possible underlying mechanisms
ترجمه فارسی عنوان
اثر محافظتی فریدلین جدا شده از آزیتا تتراکانتا لام. در برابر زخم معده ناشی از اتانول در موش صحرایی و مکانیسم های زیر ممکن است
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کلمات کلیدی
عیسی تتراکانتا، فریدلین، اتانول، زخم معده، شاخص زخم نفوذ پذیری میکرو مغناطیسی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
چکیده انگلیسی
The current study was aimed to investigate the gastroprotective effects of friedelin isolated from the hexane extract of leaves of Azima tetracantha. Ethanol-induced gastric ulcer model was used to investigate the gastroprotective effects of friedelin. Antioxidant enzymes, lipid peroxidation, nitric oxide, gastric vascular permeability, pro and anti-inflammatory cytokines and apoptosis level have been investigated. Ethanol caused severe gastric damage and friedelin pretreatment protected against its deleterious role. Antioxidant enzyme activities, anti-inflammatory cytokines, prostaglandin E2 (PGE2), constitutive nitric oxide synthase (cNOS) and mucus weight have been increased significantly. However, the vascular permeability, pro-inflammatory cytokines, inducible nitric oxide synthase (iNOS), caspase-3 and apoptosis level have significantly been decreased after friedelin ingestion. The present study has clearly demonstrated the anti-ulcer potential of friedelin, these findings suggested that friedelin could be a new useful natural gastroprotective tool against gastric ulcer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 750, 5 March 2015, Pages 167-175
Journal: European Journal of Pharmacology - Volume 750, 5 March 2015, Pages 167-175
نویسندگان
Paulrayer Antonisamy, Veeramuthu Duraipandiyan, Adithan Aravinthan, Naif Abdullah Al-Dhabi, Savarimuthu Ignacimuthu, Ki Choon Choi, Jong-Hoon Kim,