کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5827766 | 1558939 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Treatment of venous thrombosis with an oral direct factor Xa inhibitor edoxaban by single and multiple administrations in rats
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کلمات کلیدی
phosphotungstic acid hematoxylinPTAHAPTTS.E.M.VTEPulmonary embolism - آمبولی ریهTreatment effect - اثر درمانTAT - تاتVenous thromboembolism - ترومبوآمبولی وریدیVenous thrombosis - ترومبوز سیاهرگیDeep vein thrombosis - ترومبوز سیاهرگی عمقیDVT - ترومبوز سیاهرگی عمقیstandard error of mean - خطای استاندارد میانگینtwice daily - دو بار در روزactivated partial thromboplastin time - زمان ترومبوپلاستین جزئی فعال شده استprothrombin time - زمان پروترومبینoral anticoagulant - ضد انعقاد خوراکیFactor Xa - فاکتور Xaactivated Factor X - فعال عامل XThrombin–antithrombin complex - مجموعه ترومبین- آنتی ترومبینAnimal models - مدل های حیوانیfactor Xa inhibitor - مهار کننده فاکتور XaHematoxylin and Eosin - هماتوکسیلین و ائوزینBID - پیشنهادonce daily - یک بار در روز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Edoxaban is an oral and direct activated factor X inhibitor. In this study, the acute treatment effect of edoxaban on venous thrombosis is investigated in rats by single and multiple administrations, and compared to the conventional parenteral anticoagulants, enoxaparin and fondaparinux. Venous thrombus was induced in the inferior vena cava by partial stenosis plus topical application of 10% ferric chloride for 5Â min. After 1-h thrombus maturation, oral edoxaban and subcutaneous enoxaparin and fondaparinux were given. In the single administration experiment, thrombus weight was measured 1 or 4Â h after thrombus induction. In the multiple administration experiments, edoxaban was orally administered once daily (QD) and twice daily (BID) for 3 days. In the single administration experiment, oral administration of edoxaban (3.0 and 10Â mg/kg) 1Â h after thrombus formation significantly regressed the venous thrombus compared to the thrombus at 1Â h after thrombus formation. Similarly the significant venous thrombus regression was observed with enoxaparin (10Â mg/kg) and fondaparinux (0.30-3.0Â mg/kg). In the multiple administration experiment, both QD and BID administration of edoxaban at daily doses of 5 and 10Â mg/kg exerted significant treatment effects. QD administration of edoxaban including lower doses (1-10Â mg/kg) significantly reduced thrombus weight. Edoxaban administered QD and BID was effective in the treatment of venous thrombosis, and the treatment effect of edoxaban was comparable to the conventional parenteral anticoagulants. These data demonstrate the potential of edoxaban as an oral anticoagulant in the acute treatment of venous thromboembolism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 742, 5 November 2014, Pages 15-21
Journal: European Journal of Pharmacology - Volume 742, 5 November 2014, Pages 15-21
نویسندگان
Yoshiyuki Morishima, Chikako Kamisato, Yuko Honda,