کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5828490 | 1558963 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The effect of alpha-lipoic acid in ovariectomy and inflammation-mediated osteoporosis on the skeletal status of rat bone
ترجمه فارسی عنوان
اثر اسید آلفا لیپوئیک در تخریب تخمدان و استئوپروز ناشی از التهاب بر وضعیت اسکلتی استخوان موش
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کلمات کلیدی
اسید آلفا لیپوئیک، تراکم معدنی استخوان، موش تخمکگذاری شده، التهاب منیزیم سیلیکات،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
چکیده انگلیسی
Osteoporosis is a high mortality and morbidity ranged skeletal disease and results in high costs of medical care in the European Union. We evaluated the possible protective effect of alpha-lipoic acid (ALA) on rat bone metabolism in ovariectomy and inflammation-mediated osteoporosis models. Groups were designed as: (1) sham; (2) sham+inflammation; (3) ovariectomy (OVX); (4) ovariectomy+ALA-25Â mg/kg; (5) ovariectomy+ALA-50Â mg/kg; (6) ovariectomy+inflammation; (7) ovariectomy+inflammation+ALA-25Â mg/kg; and (8) ovariectomy+inflammation+ALA-50Â mg/kg groups. OVX groups were allowed to recover for two months. Then, inflammation was induced in inflammation groups by subcutaneous talc injection. ALA-25Â mg/kg and 50Â mg/kg were administered to drug groups chronically. The skeletal response was assessed by bone mineral density (BMD), osteopontin and osteocalcin measurements. Pro-inflammatory cytokine measurements (interleukin (IL)-1beta, interleukin-6, and tumor necrosis factor-alpha) were performed to observe inflammatory process. In OVX, INF and OVX+INF groups, BMD levels were lowest and osteocalcin, osteopontin, IL-1beta, IL-6, and TNF-alpha levels were highest when compared to sham group. ALA administration increased BMD levels and decreased osteocalcin, osteopontin, IL-1beta, IL-6, and TNF-alpha levels versus OVX and OVX+INF control groups. Both in senile and postmenopausal osteoporosis, the balance in coupling were destroyed on behalf of bone resorption. ALA had a protective effect on both senile and postmenopausal osteoporosis. The positive effect of this drug in these osteoporosis models might originate from its positive effects on bone turnover markers and cytokine levels. From this perspective, ALA may be a candidate for radical osteoporosis treatment both in senile and postmenopausal types clinically at the end of advanced studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 718, Issues 1â3, 15 October 2013, Pages 469-474
Journal: European Journal of Pharmacology - Volume 718, Issues 1â3, 15 October 2013, Pages 469-474
نویسندگان
Beyzagul Polat, Zekai Halici, Elif Cadirci, Abdulmecit Albayrak, Emre Karakus, Yasin Bayir, Habip Bilen, Ali Sahin, Tugba Nurcan Yuksel,