کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5828521 | 1558967 | 2013 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Molecular approaches towards development of purified natural products and their structurally known derivatives as efficient anti-cancer drugs: Current trends
ترجمه فارسی عنوان
رویکردهای مولکولی در جهت توسعه محصولات طبیعی پاک شده و مشتقات شناخته شده ساختاری آنها به عنوان داروهای ضد سرطان موثر است: روند فعلی
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
محصولات طبیعی، غربالگری بالا، رابطه فعالیت ساختاری، درمان سرطان هدفمند، مقاومت شیمیایی، فرمول بندی مواد مخدر،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
چکیده انگلیسی
Several natural products and their derivatives, either in purified or structurally identified form, exhibit immense pharmacological and biological properties, some of them showing considerable anticancer potential. Although the molecular mechanisms of action of some of these products are yet to be elucidated, extensive research in this area continues to generate new data that are clinically exploitable. Recent advancement in molecular biology, high throughput screening, biomarker identifications, target selection and genomic approaches have enabled us to understand salient interactions of natural products and their derivatives with cancer cells vis-Ã -vis normal cells. In this review we highlight the recent approaches and application of innovative technologies made to improve quality as well as efficiency of structurally identified natural products and their derivatives, particularly in small molecular forms capable of being used in “targeted therapies” in oncology. These products preferentially involve multiple mechanistic pathways and overcome chemo-resistance in tumor types with cumulative action. We also mention briefly a few physico-chemical features that compare natural products with drugs in recent natural product discovery approaches. We further report here a few purified natural products as examples that provide molecular interventions in cancer therapeutics to give the reader a glimpse of the current trends of approach for discovering useful anticancer drugs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 714, Issues 1â3, 15 August 2013, Pages 239-248
Journal: European Journal of Pharmacology - Volume 714, Issues 1â3, 15 August 2013, Pages 239-248
نویسندگان
Santu Kumar Saha, Anisur Rahman Khuda-Bukhsh,