کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5828707 | 1558979 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Different effects of dronedarone and amiodarone on pulmonary vein electrophysiology, mechanical properties and H2O2-induced arrhythmogenicity
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Different effects of dronedarone and amiodarone on pulmonary vein electrophysiology, mechanical properties and H2O2-induced arrhythmogenicity Different effects of dronedarone and amiodarone on pulmonary vein electrophysiology, mechanical properties and H2O2-induced arrhythmogenicity](/preview/png/5828707.png)
چکیده انگلیسی
Dronedarone and amiodarone are anti-atrial fibrillation agents with different potency. Pulmonary veins play a critical role in the genesis of atrial fibrillation. Oxidative stress can enhance pulmonary vein arrhythmogenesis. This study was done to compare the effects of dronedarone and amiodarone on pulmonary vein electrophysiological and mechanical properties, and oxidative stress-induced arrhythmogenecity. Conventional microelectrodes were used to record action potentials in isolated rabbit pulmonary vein specimens before and after dronedarone and amiodarone with or without the presence of H2O2 (2 mM). Dronedarone (0.1, 1 and 10 μM) concentration-dependently decreased pulmonary vein beating rates (from 2.2±0.1 to 1.9±0.1, 1.8±0.1 and 1.7±0.1 Hz, n=8, P<0.01). Amiodarone (0.1, 1 and 10 μM) also concentration-dependent decreased pulmonary vein beating rates (from 2.5±0.2 to 2.3±0.2, 2.2±0.2 and 2.0±0.2 Hz, n=7, P<0.01). However, dronedarone decreased pulmonary vein beating rates to a greater extent at 0.1 μM (12% versus 4%, P<0.005) and 1 μM (17% versus 9%, P<0.005). Dronedarone or amiodarone (0.1, 1 and 10 μM) did not change the pulmonary vein contractility. However, dronedarone (1 and 10 μM) concentration-dependent reduced pulmonary vein diastolic tension by 13±2 mg (P<0.005) and 18±3 mg (P<0.005). In contrast, amiodarone did not change pulmonary vein diastolic tension. Dronedarone (10 μM) and amiodarone (10 μM) attenuated H2O2-induced pulmonary vein burst firings from 100% to 33.3% (P<0.01), and to 0% (P<0.005), respectively. In conclusion, amiodarone and dronedarone both significantly reduced pulmonary vein spontaneous beating rates and H2O2-induced pulmonary vein arrhythmogenesis. However, only dronedarone produced pulmonary vein vasodilation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 702, Issues 1â3, 28 February 2013, Pages 103-108
Journal: European Journal of Pharmacology - Volume 702, Issues 1â3, 28 February 2013, Pages 103-108
نویسندگان
Dicky Armein Hanafy, Yao-Chang Chen, Shih-Lin Chang, Yen-Yu Lu, Yung-Kuo Lin, Yu-Hsun Kao, Shih-Ann Chen, Yi-Jen Chen,