کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5829071 | 1558982 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Protective effects of TGF-β inhibitors in a rat model of NMDA-induced retinal degeneration
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Protective effects of TGF-β inhibitors in a rat model of NMDA-induced retinal degeneration Protective effects of TGF-β inhibitors in a rat model of NMDA-induced retinal degeneration](/preview/png/5829071.png)
چکیده انگلیسی
Recent studies have shown that the retinal blood vessels are damaged in experimental models of retinal degeneration, but the mechanisms underlying their damage are not fully understood. In this study, we examined the possible role of transforming growth factor (TGF)-β in retinal neuron loss and capillary degeneration induced in rats by an intravitreal injection of N-methyl-d-aspartate (NMDA). The number of cells in the ganglion cell layer was significantly decreased 2 days after NMDA treatment, and a further decrease was observed at 7 days. Enhanced capillary degeneration was detected 7 days after NMDA treatment. Simultaneous injection of NMDA and the TGF-β inhibitor (SB431542 or LY364947) slightly but significantly attenuated the reduction in number of cells in the ganglion cell layer and almost completely prevented the enhancement of capillary degeneration. These results suggest that activation of the TGF-β signaling pathway induces neuronal and vascular cell damage in rat retina.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 699, Issues 1â3, 15 January 2013, Pages 188-193
Journal: European Journal of Pharmacology - Volume 699, Issues 1â3, 15 January 2013, Pages 188-193
نویسندگان
Kaori Ueda, Tsutomu Nakahara, Asami Mori, Kenji Sakamoto, Kunio Ishii,