کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5829523 1558996 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neutrophil recruitment is inhibited by nicotinamide in experimental pleurisy in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Neutrophil recruitment is inhibited by nicotinamide in experimental pleurisy in mice
چکیده انگلیسی
Several emerging lines of evidence support an anti-inflammatory role for nicotinamide and other vitamin B components. However, the mechanisms underlying their activity remain unclear. In the present study, we investigated the ability of nicotinamide to inhibit both neutrophil recruitment in IL-8-, LTB4- or carrageenan-induced pleurisy in mice and the rolling and adherence of neutrophils. Nicotinamide inhibited IL-8-, LTB4- and carrageenan-induced neutrophil migration, KC production and carrageenan-induced neutrophil rolling and adherence. We propose that the effects of nicotinamide in inhibiting neutrophil recruitment in carrageenan-induced pleurisy may be due to the ability of nicotinamide to inhibit the action of IL-8 and LTB4, decrease KC production, and inhibit early events that regulate leukocyte migration from blood vessels into tissue.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 685, Issues 1–3, 15 June 2012, Pages 198-204
نویسندگان
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