کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5830750 | 1559644 | 2015 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Studies on cytotoxic pregnane sapogenins from Cynanchum wilfordii
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
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چکیده انگلیسی
To investigate their cytotoxicity, seventeen C21-steroidal pregnane sapogenins 1-17 were isolated from the hydrolytic extracts of the roots of Cynanchum wilfordii. Among them, sapogenins 1-7 are new compounds, whose structures were determined by extensive analysis of spectroscopic data and X-ray crystallographic analysis. Especially, sapogenins with salicyl or vanilloyl group, and a new aberrant pregnane skeleton with ether linkage between C-12 and C-20 were found for the first time. Compound 1 revealed significant cytotoxicities on HL-60 (IC50 6.72 μM) and MCF-7 (IC50 2.89 μM), and compounds 14 and 15 also revealed strong inhibitory activities against K-562 (IC50 6.72 μM) or MCF-7 (IC50 2.49 μM), respectively.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 101, March 2015, Pages 107-116
Journal: Fitoterapia - Volume 101, March 2015, Pages 107-116
نویسندگان
Lie-Jun Huang, Bing Wang, Jian-xin Zhang, Chen Yan, Shu-Zhen Mu, Xiao-Jiang Hao,