کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5830802 | 1559648 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cardiac glycosides from the bark of Antiaris toxicaria
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Cardiac glycosides from the bark of Antiaris toxicaria Cardiac glycosides from the bark of Antiaris toxicaria](/preview/png/5830802.png)
چکیده انگلیسی
Five new cardiac glycosides (1-5, namely antiaroside Y-ZC) together with 19 known compounds were obtained from the bark of Antiaris toxicaria. Their chemical structures were determined by IR, HR-ESI-MS, 1D and 2D NMR (HSQC, 1H-1H COSY, HMBC, ROESY). The absolute configuration of sugar unit was defined by acid hydrolysis and appropriate derivatization. Compound 1 was rare 5β-H-10β-H-19-nor-cardenolide, which might derive from decarboxylative derivative of 19-COOH cardenolide. The inhibitory effects of cardiac glycosides 1-11 on the viability of NIH-H460 lung cancer cells and their induction of Nur77 expression were evaluated and preliminary structure-activity relationship (SAR) was also discussed.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 97, September 2014, Pages 71-77
Journal: Fitoterapia - Volume 97, September 2014, Pages 71-77
نویسندگان
Xiao-San Li, Meng-Jie Hu, Jie Liu, Qian Liu, Zhi-Xing Huang, Shun-Lin Li, Xiao-Jiang Hao, Xiao-Kun Zhang, Xin-Sheng Yao, Jin-Shan Tang,