کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5830915 | 1559650 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bioactivity-guided isolation of anti-inflammation flavonoids from the stems of Millettia dielsiana Harms
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موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Bioactivity-guided isolation of the EtOAc extract of the stems of Millettia dielsiana Harms yielded two new isoflavones together with nine known ones. Their structures were elucidated by analysis of the spectroscopic data including 2D NMR. All of the isolates were evaluated for their potential to inhibit the LPS-induced production of nitric oxide and TNF-α in murine macrophage RAW 264.7 cells. Among the tested compounds, Millesianin C (1) had the most potent anti-inflammatory effect decreasing NO production similar to that of dexamethasone and decreasing TNF-α secretion better than that of dexamethasone. Their structure-activity relationship was also analyzed.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 95, June 2014, Pages 154-159
Journal: Fitoterapia - Volume 95, June 2014, Pages 154-159
نویسندگان
Haoyu Ye, Wenshuang Wu, Zhuowei Liu, Caifeng Xie, Minghai Tang, Shucai Li, Jianhong Yang, Huan Tang, Kai Chen, Chaofeng Long, Aihua Peng, Yuquam Wei, Lijuan Chen,